Your best bet is to create separate Searches for each target market/ICP.
For example, you’d build a search for CEOs of eComm brands in the London, then a separate search for Founders of trucking companies in Texas.
It wouldn’t make sense to include both of these in the same leads list.
The good news is once you start the export process for your first search, you can create another search while you wait for the first search to be delivered!